From α-keto acids to nitrile oxides enabled by copper nitrate: a facile access to fused isoxazolines-Reference-Cited by-同舟云学术

From α-keto acids to nitrile oxides enabled by copper nitrate: a facile access to fused isoxazolines

Published:2022 Issue:3 Volume:9 Page:676-681
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Zhu Yuping¹,Liu Tianqi¹^ORCID,Liu Bingxin¹,Shi Houguang¹,Tan Qitao¹^ORCID,Xu Bin¹²^ORCID

Affiliation:

1. Department of Chemistry, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), Shanghai Engineering Research Center of Organ Repair, Innovative Drug Research Center, School of Medicine, Shanghai University, Shanghai 200444, China

2. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Abstract

An unprecedented generation of nitrile oxides was developed from α-keto acids and copper nitrate through a novel carbon–carbon bond cleavage mode, affording pharmacologically interesting fused isoxazolines via 1,3-dipolar cycloadditions.

Funder

National Natural Science Foundation of China

Shanghai Municipal Education Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/QO/D1QO01574E

Reference51 articles.

1. Synthesis, Spectroscopy, and Applications of Small Nitrile Oxides

2. Nitrile N-Oxides and Nitrile Imines as New Fuels for the Discovery of Novel Isocyanide-Based Multicomponent Reactions