Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance-Reference-Cited by-同舟云学术

Structure-based design of haloperidol analogues as inhibitors of acetyltransferase Eis from Mycobacterium tuberculosis to overcome kanamycin resistance

Published:2021 Issue:11 Volume:12 Page:1894-1909
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Punetha Ankita¹,Green Keith D.¹,Garzan Atefeh¹,Thamban Chandrika Nishad¹,Willby Melisa J.²,Pang Allan H.¹^ORCID,Hou Caixia¹,Holbrook Selina Y. L.¹,Krieger Kyle³,Posey James E.²,Parish Tanya³^ORCID,Tsodikov Oleg V.¹^ORCID,Garneau-Tsodikova Sylvie¹^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington, KY, 40536, USA

2. Laboratory Branch, Division of Tuberculosis Elimination, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, 30329, USA

3. Center for Global Infectious Disease Research, Seattle Children's Research Institute, 307 Westlake Avenue N, Seattle, WA, 98109, USA

Abstract

Haloperidol analogues were developed as inhibitors of the Mycobacterium tuberculosis resistance enzyme Eis to serve as kanamycin adjuvants.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00239B

Reference49 articles.

1. World Health Organization , Global tuberculosis report 2020 , Geneva , 2020 , Licence: CC BY-NC-SA 3.0 Igo

2. Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis

3. Molecular Detection of Mutations Associated with First- and Second-Line Drug Resistance Compared with Conventional Drug Susceptibility Testing of Mycobacterium tuberculosis

4. Overexpression of eis without a mutation in promoter region of amikacin- and kanamycin-resistant Mycobacterium tuberculosis clinical strain

5. Aminoglycoside Cross-Resistance in Mycobacterium tuberculosis Due to Mutations in the 5′ Untranslated Region ofwhiB7

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. N-acetyl-transferases required for iron uptake and aminoglycoside resistance promote virulence lipid production inM. marinum;2024-07-06

2. Discovery and Mechanistic Analysis of Structurally Diverse Inhibitors of Acetyltransferase Eis among FDA-Approved Drugs;Biochemistry;2023-01-19

3. Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation;RSC Medicinal Chemistry;2023

4. Discovery and development of inhibitors of acetyltransferase Eis to combat Mycobacterium tuberculosis;Methods in Enzymology;2023

5. Discovery of substituted benzyloxy-benzylamine inhibitors of acetyltransferase Eis and their anti-mycobacterial activity;European Journal of Medicinal Chemistry;2022-11