Restoring susceptibility to aminoglycosides: identifying small molecule inhibitors of enzymatic inactivation

Author:

Magaña Angel J.1,Sklenicka Jan1,Pinilla Clemencia2,Giulianotti Marc2,Chapagain Prem34ORCID,Santos Radleigh5,Ramirez Maria Soledad1,Tolmasky Marcelo E.1ORCID

Affiliation:

1. Center for Applied Biotechnology Studies, Department of Biological Science, College of Natural Sciences and Mathematics, California State University Fullerton, Fullerton, CA 92831, USA

2. Center for Translational Science, Florida International University, Port St. Lucie, FL 34987, USA

3. Department of Physics, Florida International University, Miami, FL 33199, USA

4. Biomolecular Sciences Institute, Florida International University, Miami, FL 33199, USA

5. Department of Mathematics, Nova Southeastern University, Fort Lauderdale, FL 33314, USA

Abstract

Growing resistance to antimicrobial medicines is a critical health problem that must be urgently addressed.

Funder

National Institute of Allergy and Infectious Diseases

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Reference155 articles.

1. W. H. Organization , WHO consolidated guidelines on drug-resistant tuberculosis , Geneva , 2019

2. Low-dose amikacin in the treatment of Multidrug-resistant Tuberculosis (MDR-TB)

3. Aminoglycosides: An Overview

4. Aminoglycoside modifying enzymes

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