Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models-Reference-Cited by-同舟云学术

Expanding the horizons of G protein-coupled receptor structure-based ligand discovery and optimization using homology models

Published:2015 Issue:71 Volume:51 Page:13576-13594
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Cavasotto Claudio N.¹²³,Palomba Damián¹²³

Affiliation:

1. Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET - Partner Institute of the Max Planck Society

2. Buenos Aires

3. Argentina

Abstract

We show the key role of structural homology models in GPCR structure-based lead discovery and optimization, highlighting methodological aspects, recent progress and future directions.

Funder

Agencia Nacional de Promoción Científica y Tecnológica

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2015/CC/C5CC05050B

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4. G protein-coupled receptors: novel targets for drug discovery in cancer

5. Strategies to Discover Unexpected Targets for Drugs Active at G Protein–Coupled Receptors

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