Seven-transmembrane receptors
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm908.pdf
Reference120 articles.
1. Lefkowitz, R. J. The superfamily of heptahelical receptors. Nature Cell Biol. 2, E133–E136 (2000).A historical perspective describing the origins of the field of 7TM receptor signalling in the 1970s and 1980s.
2. Dixon, R. A. et al. Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin. Nature 321, 75–79 (1986).This paper reports the cloning of the β2-adrenergic receptor, its analogy and 7TM homology with rhodopsin, and speculates on the existence of a large family of such receptors.
3. Dohlman, H. G., Thorner, J., Caron, M. G. & Lefkowitz, R. J. Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60, 653–688 (1991).
4. Lee, D. K., George, S. R. & O'Dowd, B. F. Novel G-protein-coupled receptor genes expressed in the brain: continued discovery of important therapeutic targets. Expert Opin. Ther. Targets 6, 1–18 (2002).
5. Palczewski, K. et al. Crystal structure of rhodopsin: a G protein-coupled receptor. Science 289, 739–745 (2000).Describes the crystal structure of the only 7TM receptor so far solved.
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