Dependence of norfloxacin diffusion across bilayers on lipid composition

Abstract

Antibiotic resistance is a major concern in medicine, and a better understanding of the interactions of antibiotics with the lipid molecules found in bacterial membranes is therefore highly desirable. We study the permeation of the antibiotic norfloxacin across vesicle lipid membranes of variable lipid compositions, and show that norfloxacin permeation is dependent on both the type and relative concentration of lipid molecules in the membrane.