Abstract
In this work, giant unilamellar vesicles (GUVs) were synthesized by blending the natural phospholipid 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with a photoswitchable amphiphile (1) that undergoes photoisomerization upon irradiation with UV-A (E to Z) and blue (Z to E) light. The mixed vesicles showed marked changes in behavior in response to UV light, including changes in morphology and the opening of pores. The fine control of membrane permeability with consequent cargo release could be attained by modulating either the UV irradiation intensity or the membrane composition. As a proof of concept, the photocontrolled release of sucrose from mixed GUVs is demonstrated using microscopy (phase contrast) and confocal studies. The permeability of the GUVs to sucrose could be increased to ~4 × 10–2 μm/s when the system was illuminated by UV light. With respect to previously reported systems (entirely composed of synthetic amphiphiles), our findings demonstrate the potential of photosensitive GUVs that are mainly composed of natural lipids to be used in medical and biomedical applications, such as targeted drug delivery and localized topical treatments.
Reference76 articles.
1. Systems Chemistry;Ludlow;Chem. Soc. Rev.,2008
2. Stano, P., Rampioni, G., D’Angelo, F., Altamura, E., Mavelli, F., Marangoni, R., Rossi, F., and Damiano, L. (2018). Advances in Bionanomaterials, Springer. Lecture Notes in Bioengineering.
3. Systems Chemistry;Ashkenasy;Chem. Soc. Rev.,2017
4. The Rise of the Nested Multicompartment Model in Synthetic Cell Research;Altamura;Front. Mol. Biosci.,2021
5. Miele, Y., Holló, G., Lagzi, I., and Rossi, F. (2022). Shape Deformation, Budding and Division of Giant Vesicles and Artificial Cells: A Review. Life, 12.
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献