Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative <i>in vitro</i> pharmacokinetic study of mycophenolate mofetil-Reference-Cited by-同舟云学术

Application of a gut–liver-on-a-chip device and mechanistic modelling to the quantitative in vitro pharmacokinetic study of mycophenolate mofetil

Published:2022 Issue:15 Volume:22 Page:2853-2868
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Milani Nicoló¹²^ORCID,Parrott Neil¹,Ortiz Franyuti Daniela¹^ORCID,Godoy Patricio¹,Galetin Aleksandra²^ORCID,Gertz Michael¹,Fowler Stephen¹^ORCID

Affiliation:

1. Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, Grenzacherstrasse 124, 4070, Basel, Switzerland

2. Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester, UK

Abstract

Gut–liver MPS offer attractive opportunities to study absorption and metabolism processes for orally administered drugs, especially prodrugs. Modelling and simulation must be included from the outset for robust study design and parameter generation.

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/LC/D2LC00276K

Reference50 articles.

1. Maximizing the impact of microphysiological systems with in vitro–in vivo translation

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3. Scaling and systems biology for integrating multiple organs-on-a-chip

4. Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

5. Methods of Delivering Mechanical Stimuli to Organ-on-a-Chip

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