Patient‐Derived Microphysiological Systems for Precision Medicine

Abstract

AbstractPatient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P‐MPS as an integration of patient‐derived samples, including patient‐derived cells, organoids, and induced pluripotent stem cells, into well‐defined MPSs. Emphasizing the necessity of P‐MPS development, its significance as a nonclinical assessment approach that bridges the gap between traditional in vitro models and clinical outcomes is highlighted. Additionally, guidance is provided for engineering approaches to develop microfluidic devices and high‐content analysis for P‐MPSs, enabling high biological relevance and high‐throughput experimentation. The practical implications of the P‐MPS are further examined by exploring the clinically relevant outcomes obtained from various types of patient‐derived samples. The construction and analysis of these diverse samples within the P‐MPS have resulted in physiologically relevant data, paving the way for the development of personalized treatment strategies. This study describes the significance of the P‐MPS in precision medicine, as well as its unique capacity to offer valuable insights into individual patient characteristics.