Developing an adult stem cell derived microphysiological intestinal system for predicting oral prodrug bioconversion and permeability in humans-Reference-Cited by-同舟云学术

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Developing an adult stem cell derived microphysiological intestinal system for predicting oral prodrug bioconversion and permeability in humans

Published:2024 Issue:2 Volume:24 Page:339-355
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Sharma Abhinav¹^ORCID,Jin Liang²,Wang Xue²,Wang Yue-Ting¹,Stresser David M.¹^ORCID

Affiliation:

1. Quantitative, Translational & ADME Sciences, AbbVie, Inc, 1 North Waukegan Road, North Chicago, IL 60064, USA

2. AbbVie Bioresearch Center, Worcester, MA, USA

Abstract

We sought to develop a microphysiological intestinal test system for predicting oral prodrug bioconversion and permeability in humans. The investigation included extensive comparisons of candidate in vitro cell models and deep proteomic analysis.

Funder

AbbVie

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC00843F

Reference44 articles.

1. The expanding role of prodrugs in contemporary drug design and development

2. Newly Developed Prodrugs and Prodrugs in Development; an Insight of the Recent Years

3. Prodrug strategies to overcome poor water solubility

4. The Prodrug Approach: A Successful Tool for Improving Drug Solubility

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Establishment and evaluation of on-chip intestinal barrier biosystems based on microfluidic techniques;Materials Today Bio;2024-06

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