Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides-Reference-Cited by-同舟云学术

Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides

Published:2019 Issue:48 Volume:55 Page:6850-6853
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Shimo Takenori¹²³⁴,Tachibana Keisuke¹²³⁴,Kawawaki Yuki⁵⁶⁷⁸⁴,Watahiki Yuuka⁵⁶⁷⁸⁴,Ishigaki Taku⁵⁶⁷⁸⁴,Nakatsuji Yusuke¹²³⁴,Hara Takashi¹²³⁴,Kawakami Junji⁵⁶⁷⁸⁴,Obika Satoshi¹²³⁴^ORCID

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Osaka University

3. Osaka

4. Japan

5. Department of Nanobiochemistry

6. FIRST

7. Konan University

8. Kobe 650-0047

Abstract

LNA-based splice-switching oligonucleotides containing 7-deaza-2′-deoxyguanosine or 2′-deoxyinosine avoid secondary structure formation and showed higher exon skipping activities.

Funder

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Osaka University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2019/CC/C8CC09648A

Reference36 articles.

1. Splice-switching antisense oligonucleotides as therapeutic drugs

2. Optimization of Peptide Nucleic Acid Antisense Oligonucleotides for Local and Systemic Dystrophin Splice Correction in the mdx Mouse

3. A Chemical View of Oligonucleotides for Exon Skipping and Related Drug Applications

4. Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid andd-altritol nucleic acid-modified 2′-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro

5. Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes

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