Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid andd-altritol nucleic acid-modified 2′-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro-Reference-Cited by-同舟云学术

Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid andd-altritol nucleic acid-modified 2′-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro

Published:2016 Issue:92 Volume:52 Page:13467-13470
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Le Bao T.¹²³⁴⁵,Chen Suxiang¹²³⁴⁵,Abramov Mikhail⁶⁷⁸⁹¹⁰,Herdewijn Piet⁶⁷⁸⁹¹⁰,Veedu Rakesh N.¹²³⁴⁵

Affiliation:

1. Centre for Comparative Genomics

2. Murdoch University

3. Perth – 6150

4. Australia

5. Western Australian Neuroscience Research Institute

6. Laboratory for Medicinal Chemistry

7. Rega Institute for Medical Research

8. Katholieke Universiteit Leuven

9. 3000 Leuven

10. Belgium

Abstract

We have investigated the potential of anhydrohexitol, cyclohexenyl and altritol nucleic acid-modified antisense oligos in exon skipping, and found that they efficiently inducedDmdexon 23 skipping.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2016/CC/C6CC07447B

Reference25 articles.

1. Oligonucleotide Therapies: The Past and the Present

2. Antisense oligonucleotides: modifications and clinical trials

3. 1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

4. Synthesis and Pairing Properties of Oligonucleotides Containing 3-Hydroxy-4-hydroxymethyl-1-cyclohexanyl Nucleosides

5. Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

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