Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes-Reference-Cited by-同舟云学术

Antisense oligonucleotide modified with serinol nucleic acid (SNA) induces exon skipping in mdx myotubes

Published:2017 Issue:54 Volume:7 Page:34049-34052
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Le Bao T.¹²³⁴⁵,Murayama Keiji⁶⁷⁸⁹,Shabanpoor Fazel¹⁰¹¹¹²,Asanuma Hiroyuki⁶⁷⁸⁹,Veedu Rakesh N.¹²³⁴⁵^ORCID

Affiliation:

1. Centre for Comparative Genomics

2. Murdoch University

3. Perth

4. Australia-6150

5. Perron Institute for Neurological and Translational Science

6. Department of Biomolecular Engineering

7. Nagoya University

8. Nagoya 464-8603

9. Japan

10. Florey Department of Neuroscience and Mental Health

11. University of Melbourne

12. Australia

Abstract

We investigated the potential of SNA-modified antisense oligonucleotide (AO) for exon-skipping. We found that a 20-mer SNA-AO induced efficient exon-23 skipping in the mouse dystrophin gene transcript.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA06091B

Reference20 articles.

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