Synthesis of pyrrolo[2,3-<i>d</i>]pyridazines and pyrrolo[2,3-<i>c</i>]pyridines (6-azaindoles). Experimental and theoretical study-Reference-Cited by-同舟云学术

Synthesis of pyrrolo[2,3-d]pyridazines and pyrrolo[2,3-c]pyridines (6-azaindoles). Experimental and theoretical study

Published:2024 Issue:31 Volume:22 Page:6331-6341
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Efimov Ilya V.¹^ORCID,Sultanova Yana V.²,Cicolella Alessandra³^ORCID,Talarico Giovanni³⁴^ORCID,Voskressensky Leonid G.¹^ORCID

Affiliation:

1. Research Institute of Chemistry, Molecular Design and Synthesis of Innovative Compounds for Medicine, Peoples’ Friendship University of Russia (RUDN University), 117198, Miklukho-Maklaya st, 6, Moscow, Russia

2. Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia

3. Scuola Superiore Meridionale, Largo San Marcellino, 80138, Napoli, Italy

4. Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, via Cintia, 80126 Napoli, Italy

Abstract

A new synthetic route towards 6-azaindoles (pyrrolo[2,3-c]pyridines) and pyrrolo[2,3-d]pyridazines starting from 4-aroyl pyrroles is described.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/OB/D4OB00717D

Reference35 articles.

1. Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133

2. Preparation of the HIV Attachment Inhibitor BMS-663068. Part 3. Mechanistic Studies Enable a Scale-Independent Friedel–Crafts Acylation

3. Preparation of the HIV Attachment Inhibitor BMS-663068. Part 4. Synthesis of the 6-Azaindole Core

4. Inhibitors of HIV-1 attachment: The discovery and structure–activity relationships of tetrahydroisoquinolines as replacements for the piperazine benzamide in the 3-glyoxylyl 6-azaindole pharmacophore

5. Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: Design, synthesis, structure–activity relationships, physicochemical properties and biological activity