Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry-Reference-Cited by-同舟云学术

Tracking the mechanism of covalent molecular glue stabilization using native mass spectrometry

Published:2023 Issue:24 Volume:14 Page:6756-6762
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Verhoef Carlo J. A.¹^ORCID,Kay Danielle F.²,van Dijck Lars¹,Doveston Richard G.³^ORCID,Brunsveld Luc¹^ORCID,Leney Aneika C.²^ORCID,Cossar Peter J.¹^ORCID

Affiliation:

1. Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, 5600 MB, The Netherlands

2. School of Biosciences, University of Birmingham, Birmingham, B15 2TT, UK

3. Leicester Institute of Structural and Chemical Biology and School of Chemistry, University of Leicester, Leicester, LE1 7RH, UK

Abstract

The molecular mechanisms underlying molecular glue protein complex stabilization are poorly understood. In this study, we kinetically investigate covalent molecular glue stabilization of a canonical protein–protein interaction using native mass spectrometry.

Funder

European Synchrotron Radiation Facility

Nationaal Regieorgaan Onderwijsonderzoek

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC01732J

Reference34 articles.

1. Clues to molecular glues