Rational discovery of molecular glue degraders via scalable chemical profiling-Reference-Cited by-同舟云学术

Rational discovery of molecular glue degraders via scalable chemical profiling

Published:2020-08-03 Issue:11 Volume:16 Page:1199-1207
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Mayor-Ruiz Cristina,Bauer Sophie,Brand Matthias,Kozicka Zuzanna,Siklos Marton,Imrichova Hana^ORCID,Kaltheuner Ines H.,Hahn Elisa^ORCID,Seiler Kristina,Koren Anna^ORCID,Petzold Georg,Fellner Michaela,Bock Christoph^ORCID,Müller André C.,Zuber Johannes^ORCID,Geyer Matthias,Thomä Nicolas H.,Kubicek Stefan,Winter Georg E.^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

https://www.nature.com/articles/s41589-020-0594-x.pdf

Reference48 articles.

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2. Bondeson, D. P. et al. Catalytic in vivo protein knockdown by small-molecule PROTACs. Nat. Chem. Biol. 11, 611–617 (2015).

3. Zengerle, M., Chan, K. H. & Ciulli, A. Selective small molecule induced degradation of the BET bromodomain protein BRD4. ACS Chem. Biol. 10, 1770–1777 (2015).

4. Sakamoto, K. M. et al. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proc. Natl Acad. Sci. USA 98, 8554–8559 (2001).

5. Schneekloth, J. S. Jr. et al. Chemical genetic control of protein levels: selective in vivo targeted degradation. J. Am. Chem. Soc. 126, 3748–3754 (2004).

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