Discovery of N-cyclobutylaminoethoxyisoxazole derivatives as novel sigma-1 receptor ligands with neurite outgrowth efficacy in cells

Author:

Sun Hao12345,Wang Yun-Jie678910,Shi Wen-Wen12345,Yang Fan12345,Tang Jie12345,Pang Tao678910,Yu Li-Fang12345ORCID

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development

2. School of Chemistry and Molecular Engineering

3. East China Normal University

4. Shanghai 200062

5. China

6. Jiangsu Key Laboratory of Drug Screening

7. State Key Laboratory of Natural Medicines

8. China Pharmaceutical University

9. Nanjing 210009

10. PR China

Abstract

Herein we reported a series of 14 novel derivatives based on the N-cyclobutylaminoethoxyisoxazole scaffold.

Funder

Natural Science Foundation of Jiangsu Province

National Natural Science Foundation of China

Natural Science Foundation of Shanghai

East China Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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