Synthesis and Pharmacological Evaluation of σ2 Receptor Ligands Based on a 3‐Alkoxyisoxazole Scaffold: Potential Antitumor Effects against Osteosarcoma-Reference-Cited by-同舟云学术

Synthesis and Pharmacological Evaluation of σ2 Receptor Ligands Based on a 3‐Alkoxyisoxazole Scaffold: Potential Antitumor Effects against Osteosarcoma

Published:2020-10-30 Issue:3 Volume:16 Page:524-536
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Shi Jun‐Jie¹^ORCID,Jia Kun‐Hang²,Sun Hao¹,Gunosewoyo Hendra³,Yang Fan¹,Tang Jie⁴,Luo Jian²,Yu Li‐Fang¹

Affiliation:

1. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development School of Chemistry and Molecular Engineering East China Normal University 3663 North Zhongshan Road Shanghai 200062 China

2. Shanghai Key Laboratory of Regulatory Biology Institute of Biomedical Sciences and School of Life Sciences East China Normal University 500 Dongchuan Road Shanghai 200241 China

3. School of Pharmacy and Biomedical Sciences Faculty of Health Sciences Curtin University Bentley, Perth WA 6102 Australia

4. Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University 3663 North Zhongshan Road Shanghai 200062 China

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000461

Reference71 articles.

1. Sigma receptors mediate the psychotomimetic effects of N-allylnormetazocine (SKF-10,047), but not its opioid agonistic-antagonistic properties

2. Sigma receptors: recent advances and new clinical potentials

3. A proposal for the classification of sigma binding sites

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