Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study-Reference-Cited by-同舟云学术

Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1and 5-HT1Areceptor ligand: an in vitro and computational study

Published:2015 Issue:4 Volume:6 Page:677-690
ISSN:2040-2503
Container-title:Med. Chem. Commun.
language:en
Short-container-title:Med. Chem. Commun.

Author:

Franchini Silvia¹²³,Baraldi Annamaria¹²³,Sorbi Claudia¹²³,Pellati Federica¹²³,Cichero Elena⁴⁵⁶,Battisti Umberto M.¹²³,Angeli Piero⁷⁸⁹,Cilia Antonio¹⁰¹¹¹²,Brasili Livio¹²³

Affiliation:

1. Dipartimento di Scienze della Vita

2. Università degli Studi di Modena e Reggio Emilia

3. 41125 Modena, Italy

4. Dipartimento di Farmacia

5. Università degli Studi di Genova

6. 16132 Genova, Italy

7. Dipartimento di Scienze Chimiche

8. Università degli Studi di Camerino

9. 62032 Camerino, Italy

10. Divisione Ricerca e Sviluppo

11. Recordati S.p.A.

12. 20148 Milano, Italy

Abstract

Enantioseparation and stereoselective synthesis of (1), a potent 5-HT_1AR ligand, were performed. Surprisingly, the enantiomers proved to be equipotent.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C4MD00484A

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