Chemical probing of thiotetronate bio-assembly-Reference-Cited by-同舟云学术

Chemical probing of thiotetronate bio-assembly

Published:2017 Issue:11 Volume:53 Page:1912-1915
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Havemann Judith¹²³,Yurkovich Marie E.⁴⁵³,Jenkins Robert¹²³,Harringer Sophia¹²³,Tao Weixin⁶⁷⁸⁹¹⁰,Wen Shishi⁶⁷⁸⁹¹⁰,Sun Yuhui⁶⁷⁸⁹¹⁰,Leadlay Peter F.⁴⁵³,Tosin Manuela¹²³^ORCID

Affiliation:

1. Department of Chemistry

2. University of Warwick

3. UK

4. Department of Biochemistry

5. University of Cambridge

6. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)

7. Ministry of Education

8. Wuhan University School of Pharmaceutical Sciences

9. Wuhan 430071

10. People's Republic of China

Abstract

Chemical ‘chain termination’ probes were utilised for the investigation of thiotetronate antibiotic biosynthesis in the filamentous bacteria Lentzea sp. and Streptomyces thiolactonus NRRL 15439.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/CC/C6CC09933E

Reference35 articles.

1. Conformation–activity relationships of polyketide natural products

2. Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides

3. Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides

4. C-S bond cleavage by a polyketide synthase domain

5. A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis

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