Identification of crucial bottlenecks in engineered polyketide biosynthesis-Reference-Cited by-同舟云学术

Identification of crucial bottlenecks in engineered polyketide biosynthesis

Published:2019 Issue:26 Volume:17 Page:6374-6385
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Grote Marius¹²³⁴⁵^ORCID,Kushnir Susanna¹²³⁴⁵,Pryk Niclas¹²³⁴⁵,Möller David¹²³⁴⁵,Erver Julian¹²³⁴⁵,Ismail-Ali Ahmed¹²³⁴⁵,Schulz Frank¹²³⁴⁵^ORCID

Affiliation:

1. Organische Chemie 1

2. AG Naturstoffchemie und –biochemie

3. Fakultät für Chemie und Biochemie

4. Ruhr-Universität Bochum

5. 44780 Bochum

Abstract

Quo vadis combinatorial biosynthesis: STOP signs through substrate scope limitations lower the yields in engineered polyketide biosynthesis using cis-AT polyketide synthases.

Funder

Deutsche Forschungsgemeinschaft

Bundesministerium für Bildung und Forschung

Studienstiftung des deutschen Volkes

Jürgen Manchot Stiftung

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/OB/C9OB00831D

Reference64 articles.

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2. Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization

3. Intermediates Released from a Polyether-Producing Polyketide Synthase Provide Insight into the Mechanism of Oxidative Cyclization

4. The Biosynthetic Logic of Polyketide Diversity

5. A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases

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