A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis-Reference-Cited by-同舟云学术

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A genomics-led approach to deciphering the mechanism of thiotetronate antibiotic biosynthesis

Published:2016 Issue:1 Volume:7 Page:376-385
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Tao W.¹²³⁴⁵,Yurkovich M. E.⁶⁷⁸⁹,Wen S.¹²³⁴⁵,Lebe K. E.⁶⁷⁸⁹,Samborskyy M.⁶⁷⁸⁹,Liu Y.¹²³⁴⁵,Yang A.¹²³⁴⁵,Liu Y.¹²³⁴⁵,Ju Y.¹²³⁴⁵,Deng Z.¹²³⁴⁵,Tosin M.¹⁰¹¹¹²⁹,Sun Y.¹²³⁴⁵,Leadlay P. F.⁶⁷⁸⁹

Affiliation:

1. Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)

2. Ministry of Education

3. Wuhan University School of Pharmaceutical Sciences

4. Wuhan 430071

5. People's Republic of China

6. Department of Biochemistry

7. University of Cambridge

8. Cambridge CB2 1GA

9. UK

10. Department of Chemistry

11. University of Warwick

12. Coventry CV4 7AL

Abstract

A novel mechanism is proposed for ring formation in the biosynthetic pathway to thiotetronate antibiotics thiolactomycin and Tü 3010.

Funder

Biotechnology and Biological Sciences Research Council

Natural Sciences and Engineering Research Council of Canada

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C5SC03059E

Reference64 articles.

1. The Impact of Bacterial Genomics on Natural Product Research

2. Genomic basis for natural product biosynthetic diversity in the actinomycetes

3. antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

4. Mining microbial genomes for new natural products and biosynthetic pathways

5. Bioengineering natural product biosynthetic pathways for therapeutic applications

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