Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulin-Reference-Cited by-同舟云学术

Allocolchicinoids bearing a Michael acceptor fragment for possible irreversible binding of tubulin

Published:2020 Issue:6 Volume:11 Page:696-706
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Sazanova Ekaterina S.¹²³⁴,Gracheva Iuliia A.¹²³⁴^ORCID,Allegro Diane⁵⁶⁷⁸,Barbier Pascale⁵⁶⁷⁸,Combes Sébastien⁹¹⁰¹¹¹²⁶,Svirshchevskaya Elena V.¹³¹⁴¹⁵⁴^ORCID,Fedorov Alexey Yu¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry

2. N. I. Lobachevsky State University of Nizhny Novgorod

3. 603950 Nizhny Novgorod

4. Russian Federation

5. Institute of NeuroPhysiopathology (INP) – CNRS UMR 7051

6. Aix-Marseille University

7. 13385 Marseille

8. France

9. CRCM

10. CNRS

11. Inserm

12. Institut Paoli-Calmettes

13. Laboratory of Cell Interactions

14. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

15. 117997 Moscow

Abstract

We describe an attempt to apply the concept of covalent binding towards the highly active allocolchicinoids selected on the basis of SAR analysis of previously synthesized molecules.

Funder

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/MD/D0MD00060D

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