A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication-Reference-Cited by-同舟云学术

A 7-methoxytacrine–4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

Published:2016-06-07 Issue:4 Volume:5 Page:1012-1016
ISSN:2045-4538
Container-title:Toxicology Research
language:en
Short-container-title:

Author:

Nepovimova E.¹,Korabecny J.¹,Dolezal R.¹,Nguyen T. D.¹,Jun D.¹²,Soukup O.¹,Pasdiorova M.¹,Jost P.¹,Muckova L.²,Malinak D.¹,Gorecki L.¹,Musilek K.¹,Kuca Kamil¹

Affiliation:

1. Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic

2. Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic

Abstract

Abstract Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed. Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Toxicology

Link

http://academic.oup.com/toxres/article-pdf/5/4/1012/36632067/toxres_5_4_1012.pdf

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