Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators-Reference-Cited by-同舟云学术

Design, synthesis, in silico studies and in vitro evaluation of isatin-pyridine oximes hybrids as novel acetylcholinesterase reactivators

Published:2021-01-01 Issue:1 Volume:36 Page:1369-1376
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Kitagawa Daniel A. S.¹²^ORCID,Rodrigues Rafael B.²,Silva Thiago N.³,dos Santos Wellington V.⁴⁵,da Rocha Vinicius C. V.⁶^ORCID,de Almeida Joyce S. F. D.¹^ORCID,Bernardo Leandro B.²^ORCID,Carvalho-Silva Taynara²,Ferreira Cintia N.²,da Silva Angelo A. T.⁶^ORCID,Simas Alessandro B. C.⁷^ORCID,Nepovimova Eugenie⁸^ORCID,Kuča Kamil⁸^ORCID,França Tanos C. C.¹⁸^ORCID,Cavalcante Samir F. de A.²³⁷⁸^ORCID

Affiliation:

1. Laboratory of Molecular Modelling Applied to Chemical and Biological Defense (LMACBD), Military Institute of Engineering (IME), Rio de Janeiro, Brazil

2. Brazilian Army Technological Center (CTEx), Institute of CBRN Defense (IDQBRN), Rio de Janeiro, Brazil

3. School of Pharmacy, Universidade Castelo Branco (UCB), Rio de Janeiro, Brazil

4. Emergency and Rescue Department (DSE), Rio de Janeiro State Fire Department (CBMERJ), Rio de Janeiro, Brazil

5. Universidade Estácio de Sá (UNESA), Rio de Janeiro, Brazil

6. Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Nilópolis, Brazil

7. Instituto de Pesquisas de Produtos Naturais Walter Mors (IPPN), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

8. Department of Chemistry, Faculty of Science, University of Hradec Králové, Hradec Králové, Czech Republic

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2021.1916009

Reference44 articles.

1. Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

2. Acetylcholinesterase: From 3D structure to function

3. The cholinesterases

4. Toxicology of organophosphorus compounds in view of an increasing terrorist threat

5. A primer on nerve agents: what the emergency responder, anesthesiologist, and intensivist needs to know

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