Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry-Reference-Cited by-同舟云学术

Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry

Published:2024-07-12 Issue:27 Volume:9 Page:
ISSN:2365-6549
Container-title:ChemistrySelect
language:en
Short-container-title:ChemistrySelect

Author:

Chandran Namitha¹,Bose Kuntal¹,Thekkantavida Amrutha Chandran¹,Thomas Riya Rachel¹,Anirudhan Karthika¹,Bindra Sandeep¹,Sura Sooraj¹,Hasan Haydara Ammar¹,Kumar Sunil¹,Rangarajan T. M.²,Al‐Sehemi Abdullah G.³⁴,Gahtori Prashant⁵,Kim Hoon⁶^ORCID,Mathew Bijo¹

Affiliation:

1. Department of Pharmaceutical Chemistry Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus Kochi 682 041 India

2. Department of Chemistry Sri Venketeswara College, University of Delhi New Delhi 110021 India

3. Research Center for Advanced Materials Science (RCAMS) King Khalid University Abha 61413 Saudi Arabia

4. Department of Chemistry College of Science King Khalid University Abha 61413 Saudi Arabia

5. School of Pharmacy Graphic Era Hill University Dehradun 248002 India

6. Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences Sunchon National University Suncheon 57922 Republic of Korea

Abstract

AbstractOximes, belonging to imines with the general formula of RR'C=NOH, are produced by the nucleophilic addition reaction between hydroxylamine with ketones or aldehydes, yielding corresponding aldoxime and ketoxime. The presence of hydrogen bond acceptor and donor is the classical feature of oxime‐containing structural framework. This review presents a summary of the role of oximes and its structure activity relationships including antimicrobial, anticancer, anti‐inflammatory, antihyperglycemic, insecticidal agents, along with their involvement in the treatment of organophosphorus poisoning. The review also focused on the pharmacological profile of lead molecules of several classes of oxime‐containing compounds.

Funder

King Khalid University

Publisher

Wiley

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