Comparative mode-of-action analysis following manual and automated phenotype detection in Xenopus laevis-Reference-Cited by-同舟云学术

Comparative mode-of-action analysis following manual and automated phenotype detection in Xenopus laevis

Published:2014 Issue:3 Volume:5 Page:386-396
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Drakakis Georgios¹²³⁴⁵,Hendry Adam E.⁶⁷⁸⁵,Hanson Kimberley⁶⁷⁸⁵,Brewerton Suzanne C.⁹¹⁰⁵,Bodkin Michael J.⁹¹⁰⁵,Evans David A.⁹¹⁰⁵,Wheeler Grant N.⁶⁷⁸⁵,Bender Andreas¹²³⁴⁵

Affiliation:

1. Unilever Centre for Molecular Science Informatics

2. Department of Chemistry

3. University of Cambridge

4. Cambridge CB2 1EW

5. UK

6. School of Biological Sciences

7. University of East Anglia

8. Norwich

9. Eli Lilly U.K.

10. Surrey GU206PH

Abstract

Given the increasing utilization of phenotypic screens in drug discovery also the subsequent mechanism-of-action analysis gains increased attention.

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/MD/C3MD00313B

Reference71 articles.

1. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

2. High-content screening moves to the front of the line

3. EuroPhenome: a repository for high-throughput mouse phenotyping data

4. Case Definition and Phenotype Standardization in Drug-Induced Liver Injury

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Polypharmacological in Silico Bioactivity Profiling and Experimental Validation Uncovers Sedative-Hypnotic Effects of Approved and Experimental Drugs in Rat;ACS Chemical Biology;2017-05-01

2. Decision Trees for Continuous Data and Conditional Mutual Information as a Criterion for Splitting Instances;Combinatorial Chemistry & High Throughput Screening;2016-05-10

3. Comparing Global and Local Likelihood Score Thresholds in Multiclass Laplacian-Modified Naive Bayes Protein Target Prediction;Combinatorial Chemistry & High Throughput Screening;2015-04-23

4. Cheminformatics Research at the Unilever Centre for Molecular Science Informatics Cambridge;Molecular Informatics;2015-03-10