Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd2876.pdf
Reference82 articles.
1. Fishman, M. C. & Porter, J. A. Pharmaceuticals: a new grammar for drug discovery. Nature 437, 491–493 (2005).
2. Hart, C. P. Finding the target after screening the phenotype. Drug Discov. Today 10, 513–519 (2005).
3. Crisman, T. J. et al. Understanding false positives in reporter gene assays: in silico chemogenomics approaches to prioritize cell-based HTS data. J. Chem. Inf. Model 47, 1319–1327 (2007).
4. Butte, A. The use and analysis of microarray data. Nature Rev. Drug Discov. 1, 951–960 (2002).
5. Yang, Y. H. & Speed, T. Design issues for cDNA microarray experiments. Nature Rev. Genet. 3, 579–588 (2002).
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