Scalable asymmetric synthesis of a key fragment of Bcl-2/Bcl-xL inhibitors-Reference-Cited by-同舟云学术

Scalable asymmetric synthesis of a key fragment of Bcl-2/Bcl-xL inhibitors

Published:2014 Issue:75 Volume:4 Page:39817-39821
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Laclef Sylvain¹²³⁴⁵,Taillier Catherine¹²³⁴⁵,Penloup Christine⁶⁷,Viger Aurélie⁶⁷,Brière Jean-François¹²³⁴⁵,Hardouin Christophe⁶⁷,Levacher Vincent¹²³⁴⁵

Affiliation:

1. Normandie UNIV

2. COBRA

3. UMR 6014 et FR3038; Univ Rouen; INSA Rouen; CNRS

4. IRCOF

5. 76821 Mont Saint Aignan Cedex, France

6. Oril Industrie

7. 76210 Bolbec, France

Abstract

We describe a novel asymmetric synthesis, which is applicable on a large-scale, of a chiral diamine useful as a common fragment of numerous Bcl-2 and Bcl-_xL inhibitors.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C4RA07821G

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