Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 2. Manufacture of the 1,3-Diamine Moiety and Improvement of the Final Coupling Reaction-Reference-Cited by-同舟云学术

Multikilogram Synthesis of a Potent Dual Bcl-2/Bcl-xL Antagonist. 2. Manufacture of the 1,3-Diamine Moiety and Improvement of the Final Coupling Reaction

Published:2019-11-19 Issue:5 Volume:24 Page:670-685
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Hardouin Christophe¹^ORCID,Baillard Sandrine¹,Barière François¹,Craquelin Anthony¹,Grandjean Mathieu¹,Janvier Solenn¹,Le Roux Stéphane¹,Penloup Christine¹,Russo Olivier¹

Affiliation:

1. Industrial Research Centre, Oril Industrie, 13 rue Desgenétais, 76210 Bolbec, France

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00367

Reference24 articles.

1. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

2. The Hallmarks of Cancer

3. Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

4. Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

5. Casara, P.; Le Diguarher, T.; Geneste, O.; Hickman, J. European patent EP1953161A1.

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