Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals-Reference-Cited by-同舟云学术

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

Published:2015-03-17 Issue:6 Volume:93 Page:575-580
ISSN:0818-9641
Container-title:Immunology & Cell Biology
language:en
Short-container-title:Immunol Cell Biol

Author:

House Imran G¹²³,Thia Kevin¹,Brennan Amelia J¹,Tothill Richard¹³,Dobrovic Alexander⁴,Yeh Wei Z¹,Saffery Richard⁵,Chatterton Zac⁵,Trapani Joseph A¹²³⁶,Voskoboinik Ilia¹²³⁷

Affiliation:

1. Cancer Immunology Program, Peter MacCallum Cancer Centre East Melbourne Victoria Australia

2. Sir Peter MacCallum Department of Oncology Parkville Victoria Australia

3. Department of Pathology, University of Melbourne Parkville Victoria Australia

4. Ludwig Institute for Cancer Research, Olivia Newton‐John Cancer and Wellness Centre Heidelberg (Melbourne) Victoria Australia

5. Murdoch Children's Research Institute; Department of Paediatrics; The University of Melbourne; Royal Children's Hospital Melbourne Victoria Australia

6. Department of Immunology and Microbiology Parkville Victoria Australia

7. Department of Genetics, University of Melbourne Parkville Victoria Australia

Funder

Cancer Council Victoria

Publisher

Wiley

Subject

Cell Biology,Immunology,Immunology and Allergy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1038/icb.2015.1

Reference24 articles.

1. Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack