Perforin deficiency and susceptibility to cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/cdd2009212.pdf
Reference94 articles.
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2. Trapani JA, Smyth MJ . Functional significance of the perforin/granzyme cell death pathway. Nat Rev Immunol 2002; 2: 735–747.
3. Voskoboinik I, Smyth MJ, Trapani JA . Perforin-mediated target-cell death and immune homeostasis. Nat Rev Immunol 2006; 6: 940–952.
4. Uellner R, Zvelebil MJ, Hopkins J, Jones J, MacDougall LK, Morgan BP et al. Perforin is activated by a proteolytic cleavage during biosynthesis which reveals a phospholipid-binding C2 domain. EMBO J 1997; 16: 7287–7296.
5. Voskoboinik I, Thia MC, Fletcher J, Ciccone A, Browne K, Smyth MJ et al. Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: a critical role for aspartate residues 429, 435, 483, and 485 but not 491. J Biol Chem 2005; 280: 8426–8434.
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