Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack-Reference-Cited by-同舟云学术

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

Published:2013-04-04 Issue:14 Volume:121 Page:2659-2668
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Lopez Jamie A.¹²³,Susanto Olivia¹,Jenkins Misty R.¹²³,Lukoyanova Natalya⁴,Sutton Vivien R.¹,Law Ruby H. P.⁵⁶,Johnston Angus⁷,Bird Catherina H.⁵,Bird Phillip I.⁵,Whisstock James C.⁵⁶,Trapani Joseph A.¹²⁸,Saibil Helen R.⁴,Voskoboinik Ilia¹²³⁹

Affiliation:

1. Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia;

2. Sir Peter MacCallum Department of Oncology and

3. Department of Pathology, University of Melbourne, Parkville, VIC, Australia;

4. Crystallography, Institute for Structural and Molecular Biology, Birkbeck College, London, United Kingdom;

5. Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, Australia;

6. Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Clayton, VIC, Australia; and

7. Departments of Chemical and Biomolecular Engineering,

8. Microbiology and Immunology, and

9. Genetics, University of Melbourne, Parkville, VIC, Australia

Abstract

Key Points Granzymes diffuse through perforin pores on the target cell plasma membrane.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/14/2659/1364775/2659.pdf

Reference43 articles.

1. Assembly of two types of tubules with putative cytolytic function by cloned natural killer cells.;Podack;Nature,1983

2. Electron microscopic demonstration of lesions in target cell membranes associated with antibody-dependent cellular cytotoxicity.;Dourmashkin;Clin Exp Immunol,1980

3. Homology of perforin to the ninth component of complement (C9).;Shinkai;Nature,1988

4. Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.;de Saint Basile;Nat Rev Immunol,2010

5. Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.;Shi;J Exp Med,1997

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