A synthetic cytotoxic T cell platform for rapidly prototyping TCR function
Author:
Funder
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Michael Smith Foundation for Health Research
Genome British Columbia
BioCanRx
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41698-024-00669-9.pdf
Reference65 articles.
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3. Tsimberidou, A. M. et al. T-cell receptor-based therapy: an innovative therapeutic approach for solid tumors. J. Hematol. Oncol. 14, 1–22 (2021).
4. Middleton, M. R. et al. Tebentafusp, a TCR/Anti-CD3 bispecific fusion protein targeting gp100, potently activated antitumor immune responses in patients with metastatic melanoma. Clin. Cancer Res. 26, 5869–5878 (2020).
5. Martin, S. D. et al. A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer. Oncoimmunology 7, e1371895 (2017).
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