Pre-existing AAV Capsid-specific CD8+ T Cells are Unable to Eliminate AAV-transduced Hepatocytes-Reference-Cited by-同舟云学术

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Pre-existing AAV Capsid-specific CD8+ T Cells are Unable to Eliminate AAV-transduced Hepatocytes

Published:2007-04 Issue:4 Volume:15 Page:792-800
ISSN:1525-0016
Container-title:Molecular Therapy
language:en
Short-container-title:Molecular Therapy

Author:

Li Hua,Murphy Samuel L,Giles-Davis Wynetta,Edmonson Shyrie,Xiang Zhiquan,Li Yan,Lasaro Marcio O,High Katherine A,Ertl Hildegund CJ

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology,Genetics,Molecular Biology,Molecular Medicine

Reference26 articles.

1. Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response;Manno;Nat Med,2006

2. Correction of hemophilia B in canine and murine models using recombinant adeno-associated viral vectors;Snyder;Nat Med,1999

3. Sustained phenotypic correction of hemophilia B dogs with a factor IX null mutation by liver-directed gene therapy;Mount;Blood,2002

4. Sustained high-level expression of human factor IX (hFIX) after liver-targeted delivery of recombinant adeno-associated virus encoding the hFIX gene in rhesus macaques;Nathwani;Blood,2002

5. Identification of mouse AAV capsid-specific CD8+ T cell epitopes;Sabatino;Mol Ther,2005

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1. Analysis of hepatic lentiviral vector transduction; implications for preclinical studies and clinical gene therapy protocols;2024-08-21

2. Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer;Human Gene Therapy;2024-07-01

3. Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors;Molecular Therapy - Methods & Clinical Development;2022-12

4. Regulatory Consideration for the Nonclinical Safety Assessment of Gene Therapies;Human Gene Therapy;2022-09-14

5. Immunogenicity assessment of AAV-based gene therapies: An IQ consortium industry white paper;Molecular Therapy - Methods & Clinical Development;2022-09

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