Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer-Reference-Cited by-同舟云学术

Pre-Existing Immunity to a Nucleic Acid Contaminant-Derived Antigen Mediates Transaminitis and Resultant Diminished Transgene Expression in a Mouse Model of Hepatic Recombinant Adeno-Associated Virus-Mediated Gene Transfer

Published:2024-07-01 Issue:13-14 Volume:35 Page:477-489
ISSN:1043-0342
Container-title:Human Gene Therapy
language:en
Short-container-title:Human Gene Therapy

Author:

Brimble Mark A.¹^ORCID,Morton Christopher L.²,Winston Stephen M.²³,Reeves Isaiah L.²³,Spence Yunyu²,Cheng Pei-Hsin²,Zhou Junfang²,Nathwani Amit C.⁴,Thomas Paul G.¹,Souquette Aisha⁵^ORCID,Davidoff Andrew M.²³

Affiliation:

1. Departments of, Host Microbe Interactions, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

2. Departments of, Surgery, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

3. Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

4. Research Department of Haematology, UCL Cancer Institute, University College London, London, United Kingdom.

5. Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Publisher

Mary Ann Liebert Inc

Link

https://www.liebertpub.com/doi/pdf/10.1089/hum.2023.188

Reference42 articles.

1. Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

2. Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy

3. AAV5–Factor VIII Gene Transfer in Severe Hemophilia A

4. Gene Therapy in Patients with the Crigler–Najjar Syndrome

5. Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A

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