Abstract
AbstractA cyclic tetrapeptide, designated massiliamide, was isolated from the liquid culture of the Gram-negative bacterium Massilia albidiflava DSM 17472T. The structure was elucidated through extensive spectroscopic analysis, including HR-MS and 1D and 2D NMR experiments. The absolute configuration was determined using the Marfey´s method. Massiliamide showed potent inhibitory activity towards tyrosinase with an IC50 value of 1.15 µM and no cytotoxicity.
Funder
Kementerian Riset, Teknologi dan Pendidikan Tinggi
Deutsches Zentrum für Infektionsforschung
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology
Reference20 articles.
1. La Scola B, Birtles RJ, Mallet MN, Raoult D. Massilia timonae gen. nov., sp. nov., isolated from blood of an immunocompromised patient with cerebellar lesions. J Clin Microbiol. 1998;36:2847–52.
2. Lindquist D, Murril D, Burran WP, Winans G, Janda MJ, Probert W. Characteristics of Massilia timonae and Massilia timonae-like isolates from human patients, with an emended description of the species. J Clin Microbiol. 2003;41:192–6.
3. Ofek M, Hadar Y, Minz D. Ecology of root colonizing Massilia (Oxalobacteraceae). PLoS ONE. 2012;7:e40117.
4. Euzéby JP. List of bacterial names with standing in nomenclature: a folder available on the internet. Int J Syst Bacteriol. 1997;47:590–2.
5. Baldani JI, Rouws L, Cruz LM, Olivares FL, Schmid M, Hartmann A. The family Oxalobacteraceae. In: The Prokaryotes - Alphaproteobacteria and Betaproteobacteria. Rosenberg E, DeLong EF, Lory S, Stackebrandt E, Thompson F, editors. Heidelberg: Springer Berlin, 2014. p. 919–74.
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