Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy-Reference-Cited by-同舟云学术

Influence of genetic variants and antiepileptic drug co-treatment on lamotrigine plasma concentration in Mexican Mestizo patients with epilepsy

Published:2020-06-02 Issue:6 Volume:20 Page:845-856
ISSN:1470-269X
Container-title:The Pharmacogenomics Journal
language:en
Short-container-title:Pharmacogenomics J

Author:

Ortega-Vázquez Alberto,Fricke-Galindo Ingrid,Dorado Pedro,Jung-Cook Helgi,Martínez-Juárez Iris E.,Monroy-Jaramillo Nancy,Rojas-Tomé Irma S.,Peñas-Lledó Eva,Llerena Adrián,López-López Marisol^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,Genetics,Molecular Medicine

Link

http://www.nature.com/articles/s41397-020-0173-2.pdf

Reference63 articles.

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2. Leach MJ, Marden CM, Miller AA. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug: II. Neurochemical studies on the mechanism of action. Epilepsia. 1986;27:490–97.

3. Singkham N, Towanabut S, Lertkachatarn S, Punyawudho B. Influence of the UGT2B7 -161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients. Eur J Clin Pharm. 2013;69:1285–91.

4. Garnett WR. Lamotrigine: pharmacokinetics. J Child Neurol. 1997;12:S10–5.

5. Inoue K, Yamamoto Y, Suzuki E, Takahashi T, Umemura A, Takahashi Y, et al. Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy. Eur J Clin Pharm. 2016;72:555–62.

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5. Bearing variant alleles at uridine glucuronosyltransferase polymorphisms UGT2B7 -161C > T (rs7668258) or UGT1A4*3 c.142 T > G (rs2011425) has no relevant consequences for lamotrigine troughs in adults with epilepsy;European Journal of Clinical Pharmacology;2023-06-20