Optimisation of pharmacotherapy in psychiatry through therapeutic drug monitoring, molecular brain imaging and pharmacogenetic tests: Focus on antipsychotics

Author:

Hart Xenia Marlene12ORCID,Gründer Gerhard23,Ansermot Nicolas4,Conca Andreas5ORCID,Corruble Emmanuelle67,Crettol Severine4,Cumming Paul89ORCID,Hefner Gudrun10,Frajerman Ariel67ORCID,Howes Oliver1112ORCID,Jukic Marin M.1314ORCID,Kim Euitae15,Kim Seoyoung16,Maniscalco Ignazio5ORCID,Moriguchi Sho2ORCID,Müller Daniel J.171819ORCID,Nakajima Shinichiro2ORCID,Osugo Martin1112,Paulzen Michael2021,Ruhe Henricus Gerardus2223ORCID,Scherf-Clavel Maike17,Schoretsanitis Georgios24ORCID,Serretti Alessandro25ORCID,Spina Edoardo26ORCID,Spigset Olav2728,Steimer Werner29,Süzen Sinan H.30,Uchida Hiroyuki2,Unterecker Stefan17,Vandenberghe Frederik4ORCID,Verstuyft Celine731ORCID,Zernig Gerald3233,Hiemke Christoph34ORCID,Eap Chin B.4353637ORCID

Affiliation:

1. Department of Molecular Neuroimaging, Medical Faculty Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany

2. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan

3. German Center for Mental Health (DZPG), Partner Site Mannheim, Heidelberg, Germany

4. Department of Psychiatry, Unit of Pharmacogenetics and Clinical Psychopharmacology, Center for Psychiatric Neuroscience, Lausanne University Hospital, Prilly, Switzerland

5. Dipartimento di Psichiatria, Comprensorio Sanitario di Bolzano, Bolzano, Italy

6. Service Hospitalo-Universitaire de Psychiatrie, Hôpital de Bicêtre, Université Paris-Saclay, AP-HP, Le Kremlin-Bicêtre, France

7. Equipe MOODS, Inserm U1018, CESP (Centre de Recherche en Epidémiologie et Sante des Populations), Le Kremlin-Bicêtre, France

8. Department of Nuclear Medicine, Bern University Hospital, Bern, Switzerland

9. School of Psychology and Counseling, Queensland University of Technology, Brisbane, Australia

10. Forensic Psychiatry, Vitos Clinic for Forensic Psychiatry, Eltville, Germany

11. Department of Psychosis Studies, IoPPN, King’s College London, London, UK

12. Faculty of Medicine, Institute of Clinical Sciences (ICS), Imperial College London, London, UK

13. Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

14. Pharmacogenetics Section, Department of Physiology and Pharmacology, Karolinska Institutet, Solna, Sweden

15. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea

16. Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea

17. Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Würzburg, Würzburg, Germany

18. Pharmacogenetics Research Clinic, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada

19. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

20. Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany

21. JARA – Translational Brain Medicine, Alexianer Center for Mental Health, Aachen, Germany

22. Department of Psychiatry, Radboudumc, Nijmegen, Netherlands

23. Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands

24. Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland

25. Department of Medicine and Surgery, Kore University of Enna, Enna, Italy

26. Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy

27. Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway

28. Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway

29. Institute of Clinical Chemistry and Pathobiochemistry, Technical University Munich, Munich, Germany

30. Department of Pharmaceutic Toxicology, Faculty of Pharmacy, Ankara University, Ankara, Turkey

31. Department of Molecular Genetics, Pharmacogenetics and Hormonology, Bicêtre University Hospital Paris-Saclay, Assistance Publique-Hôpitaux de Paris, Paris, France

32. Department of Pharmacology, Medical University Innsbruck, Hall in Tirol, Austria

33. Private Practice for Psychotherapy and Court-Certified Witness, Hall in Tirol, Austria

34. Department of Psychiatry and Psychotherapy and Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center of Mainz, Mainz, Germany

35. School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland

36. Center for Research and Innovation in Clinical Pharmaceutical Sciences, University of Lausanne, Lausanne, Switzerland

37. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Lausanne, Switzerland

Funder

Overseas Research Fellow Award

Japan Society for the Promotion of Science

ZonMW

de Hetrsenstichting

Dutch Ministry of Health

Boehringer Ingelheim

Institute for Quality and Efficiency in Health Care

Janssen-Cilag, Lundbeck, MindMed, Otsuka, Recordati, Roche, ROVI, and Takeda

Beckley Psytech and Boehringer Ingelheim

Abbott

Abbvie

Angelini

Astra Zeneca

Clinical Data

Boheringer

Bristol Myers Squibb

Eli Lilly

GlaxoSmithKline

Innovapharma

Italfarmaco

Janssen

Lundbeck

Naurex

Pfizer

Polifarma

Sanofi

Servier

Taliaz

Daiichi Sankyo, Eisai, Mochida, Otsuka, and Sumitomo Pharma

Eisai, Lundbeck, Meiji Seika Pharma, Otsuka, and Sumitomo Pharma

Lundbeck, Sumitomo Pharma, Takeda Pharmaceutical Company, and Boehringer Ingelheim Japan

Takeda Pharmaceutical Company

Astellas Pharma

Signant Health

Asahi Quality & Innovations, Ltd

Sumitomo Pharma, Meiji- Seika Pharma, Otsuka Pharmaceutical, and MSD

Publisher

Informa UK Limited

Reference722 articles.

1. Acacia Pharma Inc. 2020. Amisulpride: highlights of prescribing information. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209510s000lbl.pdf

2. Antipsychotic efficacy in relation to plasma levels of clozapine;Ackenheil M;Arzneimittelforschung,1976

3. Haloperidol versus placebo for schizophrenia

4. Administration USFD clinical pharmacology and biopharmaceutics review of lurasidone. 2010. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/200603Orig1s000ClinPharmR.pdf

5. Administration USFD Navane. 2009. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/016584s059lbl.pdf

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