Mutational signatures: emerging concepts, caveats and clinical applications
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
https://www.nature.com/articles/s41568-021-00377-7.pdf
Reference176 articles.
1. Nik-Zainal, S. et al. Mutational processes molding the genomes of 21 breast cancers. Cell 149, 979–993 (2012). This study presents catalogues of somatic mutations from 21 breast cancers, the respective mutational signatures of which were extracted by mathematical methods.
2. Alexandrov, L. B. et al. Signatures of mutational processes in human cancer. Nature 500, 415–421 (2013). This study reports 21 distinct mutational signatures extracted from several cancer types, which form the basis of COSMIC mutational signatures v2.
3. Alexandrov, L. B. et al. The repertoire of mutational signatures in human cancer. Nature 578, 94–101 (2020). This study reports the largest number of mutational signatures to date, which form the basis of COSMIC mutational signatures v3, and introduces DBSs and IDs.
4. Degasperi, A. et al. A practical framework and online tool for mutational signature analyses show inter-tissue variation and driver dependencies. Nat. Cancer 1, 249–263 (2020). This study introduces a practical framework and Signal, an online tool, to analyse mutational signatures. It also reports evidence of tissue-specific variability in mutational signatures, which may impact tumour classification and clinical application.
5. Li, Y. et al. Patterns of somatic structural variation in human cancer genomes. Nature 578, 112–121 (2020).
Cited by 162 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. A review on trends in development and translation of omics signatures in cancer;Computational and Structural Biotechnology Journal;2024-12
2. Unveiling pathogenesis and therapeutic targets of metastatic breast cancer through sparse modeling of genomic landscape;Computational and Structural Biotechnology Reports;2024-12
3. RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability;Nature Communications;2024-09-05
4. Mutational mechanisms in multiply relapsed pediatric acute lymphoblastic leukemia;Leukemia;2024-09-04
5. Cancer drug-tolerant persister cells: from biological questions to clinical opportunities;Nature Reviews Cancer;2024-09-02
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3