RAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability
Author:
Funder
U.S. Department of Health & Human Services | NIH | National Cancer Institute
American Association for Cancer Research
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41467-024-51784-x.pdf
Reference88 articles.
1. Gómez-González, B. & Aguilera, A. Transcription-mediated replication hindrance: a major driver of genome instability. Genes Dev. 33, 1008–1026 (2019).
2. Goehring, L., Huang, T. T. & Smith, D. J. Transcription–replication conflicts as a source of genome instability. Annu. Rev. Genet. 57, 157–179 (2023).
3. Thomas, M., White, R. L. & Davis, R. W. Hybridization of RNA to double-stranded DNA: formation of R-loops. Proc. Natl Acad. Sci. USA 73, 2294–2298 (1976).
4. Petermann, E., Lan, L. & Zou, L. Sources, resolution and physiological relevance of R-loops and RNA–DNA hybrids. Nat. Rev. Mol. Cell Biol. 23, 521–540 (2022).
5. Crossley, M. P., Bocek, M. & Cimprich, K. A. R-loops as cellular regulators and genomic threats. Mol. Cell 73, 398–411 (2019).
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