Kappa Antagonist JDTic in Phase 1 Clinical Trial
Author:
Publisher
Springer Science and Business Media LLC
Subject
Psychiatry and Mental health,Pharmacology
Link
http://www.nature.com/articles/npp201574.pdf
Reference6 articles.
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2. Bruchas MR, Land BB, Chavkin C (2010). The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res 1314: 44–55.
3. Buda JJ, Carroll FI, Kosten TR, Swearingen D, Walters BB (2015). A double-blind, placebo-controlled trial to evaluate the safety, tolerability, and pharmacokinetics of single, escalating oral doses of JDTic. Neuropsychopharmacology (this issue).
4. Carroll FI, Carlezon WA Jr (2013). Development of κ opioid receptor antagonists. J Med Chem 56: 2178–2195.
5. Ehrich E, Turncliff R, Du Y, Leigh-Pemberton R, Fernandez E, Jones R et al (2014). Evaluation of opioid modulation in major depressive disorder. Neuropsychopharmacology e-pub ahead of print 18 December 2014 doi:10.1038/npp.2014.330.
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