Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor-Reference-Cited by-同舟云学术

Discovery and Binding Mechanism of Pyrazoloisoquinoline-Based Novel β-Arrestin Inverse Agonists of the Kappa-Opioid Receptor

Published:2023-03-29 Issue:7 Volume:66 Page:5154-5170
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jung Jae-Hoon¹,Jang In Hee²³,Yang Moon Young⁴,Kim Sunhong²⁵,Kim Soo-Kyung⁴,Goddard William A.⁴^ORCID,Kim Yong-Chul¹⁶^ORCID

Affiliation:

1. School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea

2. Disease Target Structure Research Center, Korea Research Institute of Bioscience & Biotechnology, Daejeon 34141, Republic of Korea

3. College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea

4. Materials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, United States

5. Department of Biomolecular Science, KRIBB School of Biological Science, Korea University of Science and Technology, Daejeon 34113, Republic of Korea

6. Center for AI-Applied High Efficiency Drug Discovery (AHEDD), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea

Funder

National Heart, Lung, and Blood Institute

Gwangju Institute of Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00064

Reference48 articles.

1. 75 years of opioid research: the exciting but vain quest for the Holy Grail

2. Endogenous opiates and behavior: 2010

3. Extending pharmacological spectrum of opioids beyond analgesia: Multifunctional aspects in different pathophysiological states

4. The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence

5. Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction

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