Target engagement and drug residence time can be observed in living cells with BRET-Reference-Cited by-同舟云学术

Target engagement and drug residence time can be observed in living cells with BRET

Published:2015-12 Issue:1 Volume:6 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Robers Matthew B.,Dart Melanie L.,Woodroofe Carolyn C.,Zimprich Chad A.,Kirkland Thomas A.,Machleidt Thomas,Kupcho Kevin R.,Levin Sergiy,Hartnett James R.,Zimmerman Kristopher,Niles Andrew L.,Ohana Rachel Friedman,Daniels Danette L.,Slater Michael,Wood Monika G.,Cong Mei,Cheng Yi-Qiang,Wood Keith V.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/ncomms10091.pdf

Reference56 articles.

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3. Tummino, P. J. & Copeland, R. A. Residence time of receptor-ligand complexes and its effect on biological function. Biochemistry 47, 5481–5492 (2008).

4. Bantscheff, M. et al. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. Nat. Biotechnol. 29, 255–265 (2011).

5. Becher, I. et al. Chemoproteomics reveals time-dependent binding of histone deacetylase inhibitors to endogenous repressor complexes. ACS Chem. Biol. 9, 1736–1746 (2014).

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