Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story-Reference-Cited by-同舟云学术

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Exploring 2-Sulfonylpyrimidine Warheads as Acrylamide Surrogates for Targeted Covalent Inhibition: A BTK Story

Published:2024-08-09 Issue:16 Volume:67 Page:13572-13593
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Moraru Ruxandra¹,Valle-Argos Beatriz²,Minton Annabel²,Buermann Lara²,Pan Suyin¹^ORCID,Wales Thomas E.³,Joseph Raji E.⁴,Andreotti Amy H.⁴^ORCID,Strefford Jonathan C.²,Packham Graham²,Baud Matthias G. J.¹^ORCID

Affiliation:

1. School of Chemistry and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, U.K.

2. Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K.

3. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

4. Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa 50011, United States

Funder

Engineering and Physical Sciences Research Council

University of Southampton

National Institute of Allergy and Infectious Diseases

Cancer Research UK

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01927

Reference85 articles.

1. Structure-based design of targeted covalent inhibitors

2. The resurgence of covalent drugs

3. Design of Reversible, Cysteine-Targeted Michael Acceptors Guided by Kinetic and Computational Analysis

4. Expanding the Armory: Predicting and Tuning Covalent Warhead Reactivity

5. Bioconjugation with Maleimides: A Useful Tool for Chemical Biology

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