tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis-Reference-Cited by-同舟云学术

tracerDB: a crowdsourced fluorescent tracer database for target engagement analysis

Published:2024-07-05 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Dopfer Johannes^ORCID,Vasta James D.,Müller Susanne^ORCID,Knapp Stefan,Robers Matthew B.^ORCID,Schwalm Martin P.^ORCID

Abstract

AbstractInvestigating ligand-protein complexes is essential in the areas of chemical biology and drug discovery. However, detailed information on key reagents such as fluorescent tracers and associated data for the development of widely used bioluminescence resonance energy transfer (BRET) assays including NanoBRET, time-resolved Förster resonance energy transfer (TR-FRET) and fluorescence polarization (FP) assays are not easily accessible to the research community. We created tracerDB, a curated database of validated tracers. This resource provides an open access knowledge base and a unified system for tracer and assay validation. The database is freely available at https://www.tracerdb.org/.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-49896-5.pdf

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