Target 2035 – update on the quest for a probe for every protein

Author:

Müller Susanne12ORCID,Ackloo Suzanne3,Al Chawaf Arij4,Al-Lazikani Bissan56,Antolin Albert57,Baell Jonathan B.89ORCID,Beck Hartmut10,Beedie Shaunna11,Betz Ulrich A. K.12,Bezerra Gustavo Arruda11,Brennan Paul E.13ORCID,Brown David14,Brown Peter J.3,Bullock Alex N.11,Carter Adrian J.15,Chaikuad Apirat12,Chaineau Mathilde16ORCID,Ciulli Alessio17ORCID,Collins Ian7,Dreher Jan10,Drewry David1819,Edfeldt Kristina20,Edwards Aled M.3,Egner Ursula21,Frye Stephen V.1922,Fuchs Stephen M.23,Hall Matthew D.24,Hartung Ingo V.25ORCID,Hillisch Alexander10,Hitchcock Stephen H.26,Homan Evert27,Kannan Natarajan28,Kiefer James R.29,Knapp Stefan12,Kostic Milka30ORCID,Kubicek Stefan31,Leach Andrew R.32,Lindemann Sven33ORCID,Marsden Brian D.1134,Matsui Hisanori35,Meier Jordan L.36ORCID,Merk Daniel137,Michel Maurice27,Morgan Maxwell R.3ORCID,Mueller-Fahrnow Anke21,Owen Dafydd R.38,Perry Benjamin G.39ORCID,Rosenberg Saul H.40,Saikatendu Kumar Singh41,Schapira Matthieu342,Scholten Cora43,Sharma Sujata44,Simeonov Anton24,Sundström Michael45,Superti-Furga Giulio3146,Todd Matthew H.47ORCID,Tredup Claudia12,Vedadi Masoud342ORCID,von Delft Frank11484950,Willson Timothy M.19,Winter Georg E.31,Workman Paul67,Arrowsmith Cheryl H.351

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Frankfurt 60438, Germany

2. Structural Genomics Consortium, BMLS, Goethe University Frankfurt, Frankfurt 60438, Germany

3. Structural Genomics Consortium, University of Toronto, Toronto, Ontario, M5G 1L7, Canada

4. University of Toronto, Toronto, Ontario, M5G 1L7, Canada

5. Department of Data Science, The Institute of Cancer Research, London, SM2 5NG, UK

6. CRUK ICR/Imperial Convergence Science Centre, London, SM2 5NG, UK

7. Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, UK

8. Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia

9. School of Pharmaceutical Sciences, Nanjing Tech University, No. 30 South Puzhu Road, Nanjing 211816, People's Republic of China

10. Research and Development, Bayer AG, Pharmaceuticals, 42103 Wuppertal, Germany

11. Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK

12. Merck KGaA, Darmstadt, Germany

13. Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, University of Oxford, Oxford, OX3 7FZ, UK

14. Institut Recherches de Servier, 125 Chemin de Ronde, 78290 Croissy, France

15. Discovery Research, Boehringer Ingelheim, 55216 Ingelheim am Rhein, Germany

16. Early Drug Discovery Unit (EDDU), Montreal Neurological Institute-Hospital, McGill University, Montreal, QC, Canada

17. School of Life Sciences, Division of Biological Chemistry and Drug Discovery, University of Dundee, James Black Centre, Dundee, UK

18. Structural Genomics Consortium, UNC Eshelman School of Pharmacy, Chapel Hill, NC, USA

19. Lineberger Comprehensive Cancer Center, Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA

20. Structural Genomics Consortium, Department of Medicine, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

21. Nuvisan Innovation Campus Berlin GmbH, Müllerstraße 178, 13353, Berlin, Germany

22. Center for Integrative Chemical Biology and Drug Discovery, Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA

23. Institute for Protein Innovation, Boston, MA, USA

24. National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, USA

25. Medicinal Chemistry, Global R&D, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany

26. Takeda California, 9625 Towne Centre Drive, San Diego, California 92121, USA

27. Science for Life Laboratory, Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden

28. Institute of Bioinformatics and Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA

29. Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA

30. Department of Cancer Biology and Chemical Biology Program, Dana-Farber Cancer Institute, 450 Brookline Ave, Boston, MA 02215, USA

31. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

32. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK

33. Strategic Innovation, Global R&D, Merck Healthcare KGaA, Frankfurter Straße 250, 64293, Darmstadt, Germany

34. Kennedy Institute of Rheumatology, NDORMS, University of Oxford, UK

35. Neuroscience Drug Discovery Unit, Research, Takeda Pharmaceutical Company Limited, Fujisawa, Kanagawa, Japan

36. Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA

37. LMU Munich, Department of Pharmacy, Chair of Pharmaceutical and Medicinal Chemistry, 81377 Munich, Germany

38. Discovery Network Group, Pfizer Medicine Design, Cambridge, MA 02139, USA

39. Drugs for Neglected Diseases initiative, 15 Chemin Camille Vidart, Geneva 1202, Switzerland

40. AbbVie, North Chicago, Illinois, USA

41. Global Research Externalization, Takeda California, Inc., 9625 Towne Center Drive, San Diego, CA 92121, USA

42. Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

43. Research and Development, Bayer AG, Pharmaceuticals, 13353 Berlin, Germany

44. Structural & Protein Sciences, Discovery Sciences, Janssen Research & Development, 1400 McKean Rd, Spring House, PA 19477, USA

45. Division of Rheumatology, Department of Medicine Solna, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden

46. Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

47. School of Pharmacy, University College London, London, WC1N 1AX, UK

48. Diamond Light Source Ltd, Harwell Science and Innovation Campus, Didcot OX11 0QX, UK

49. Department of Biochemistry, University of Johannesburg, Auckland Park 2006, South Africa

50. Research Complex at Harwell, Harwell Science and Innovation Campus, Didcot OX11 0FA, UK

51. Princess Margaret Cancer Centre, Toronto, Ontario, M5G 1L7, Canada

Abstract

Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. Target 2035 aims to develop a pharmacological modulator for every protein in the human proteome to fill this gap.

Funder

Chordoma Foundation

Genome Canada

National Cancer Institute

Mark Foundation For Cancer Research

Innovative Medicines Initiative

Cancer Research UK

Seventh Framework Programme

Wellcome Trust

Agència per a la Competitivitat de l'Empresa

European Molecular Biology Laboratory

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

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