A novel rapamycin analog is highly selective for mTORC1 in vivo-Reference-Cited by-同舟云学术

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A novel rapamycin analog is highly selective for mTORC1 in vivo

Published:2019-07-19 Issue:1 Volume:10 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Schreiber Katherine H.,Arriola Apelo Sebastian I.,Yu Deyang,Brinkman Jacqueline A.,Velarde Michael C.,Syed Faizan A.,Liao Chen-Yu^ORCID,Baar Emma L.,Carbajal Kathryn A.,Sherman Dawn S.,Ortiz Denise,Brunauer Regina^ORCID,Yang Shany E.,Tzannis Stelios T.,Kennedy Brian K.,Lamming Dudley W.^ORCID

Funder

American Diabetes Association

American Heart Association

U.S. Department of Health & Human Services | NIH | National Cancer Institute

U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences

UW | School of Medicine and Public Health, University of Wisconsin-Madison

U.S. Department of Health & Human Services | NIH | National Institute on Aging

Aeonian Pharmaceuticals

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-019-11174-0.pdf

Reference70 articles.

1. Bjedov, I. et al. Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab. 11, 35–46 (2010).

2. Harrison, D. E. et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460, 392–395 (2009).

3. Robida-Stubbs, S. et al. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 15, 713–724 (2012).

4. Powers, R. W. 3rd, Kaeberlein, M., Caldwell, S. D., Kennedy, B. K. & Fields, S. Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev. 20, 174–184 (2006).

5. Majumder, S. et al. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1beta and enhancing NMDA signaling. Aging Cell 11, 326–335 (2012).

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