The genomic landscape of Mexican Indigenous populations brings insights into the peopling of the Americas
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Published:2021-10-12
Issue:1
Volume:12
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
García-Ortiz HumbertoORCID, Barajas-Olmos Francisco, Contreras-Cubas Cecilia, Cid-Soto Miguel Ángel, Córdova Emilio J., Centeno-Cruz FedericoORCID, Mendoza-Caamal Elvia, Cicerón-Arellano Isabel, Flores-Huacuja Marlen, Baca Paulina, Bolnick Deborah A.ORCID, Snow Meradeth, Flores-Martínez Silvia Esperanza, Ortiz-Lopez RocioORCID, Reynolds Austin W., Blanchet Antonio, Morales-Marín Mirna, Velázquez-Cruz Rafael, Kostic Aleksandar DavidORCID, Galaviz-Hernández CarlosORCID, García-Zapién Alejandra Guadalupe, Jiménez-López José Concepción, León-Reyes Guadalupe, Salas-Bautista Eva Gabriela, Lazalde-Ramos Blanca Patricia, Jiménez-Ruíz Juan LuisORCID, Salas-Martínez Guadalupe, Ramos-Madrigal JazmínORCID, Mirzaeicheshmeh Elaheh, Saldaña-Alvarez Yolanda, del Carmen Abrahantes-Pérez MaríaORCID, Loeza-Becerra Francisco, Mojica-Espinosa RaúlORCID, Sánchez-Quinto Federico, Rangel-Villalobos Héctor, Sosa-Macías Martha, Sánchez-Corona José, Rojas-Martinez AugustoORCID, Martínez-Hernández Angélica, Orozco LorenaORCID
Abstract
AbstractThe genetic makeup of Indigenous populations inhabiting Mexico has been strongly influenced by geography and demographic history. Here, we perform a genome-wide analysis of 716 newly genotyped individuals from 60 of the 68 recognized ethnic groups in Mexico. We show that the genetic structure of these populations is strongly influenced by geography, and our demographic reconstructions suggest a decline in the population size of all tested populations in the last 15–30 generations. We find evidence that Aridoamerican and Mesoamerican populations diverged roughly 4–9.9 ka, around the time when sedentary farming started in Mesoamerica. Comparisons with ancient genomes indicate that the Upward Sun River 1 (USR1) individual is an outgroup to Mexican/South American Indigenous populations, whereas Anzick-1 was more closely related to Mesoamerican/South American populations than to those from Aridoamerica, showing an even more complex history of divergence than recognized so far.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference76 articles.
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