The genetics of Mexico recapitulates Native American substructure and affects biomedical traits-Reference-Cited by-同舟云学术

The genetics of Mexico recapitulates Native American substructure and affects biomedical traits

Published:2014-06-13 Issue:6189 Volume:344 Page:1280-1285
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Moreno-Estrada Andrés¹,Gignoux Christopher R.²,Fernández-López Juan Carlos³,Zakharia Fouad¹,Sikora Martin¹,Contreras Alejandra V.³,Acuña-Alonzo Victor⁴⁵,Sandoval Karla¹,Eng Celeste⁶,Romero-Hidalgo Sandra³,Ortiz-Tello Patricia¹,Robles Victoria¹,Kenny Eimear E.¹,Nuño-Arana Ismael⁷,Barquera-Lozano Rodrigo⁴,Macín-Pérez Gastón⁴,Granados-Arriola Julio⁸,Huntsman Scott⁶,Galanter Joshua M.⁶²,Via Marc⁶,Ford Jean G.⁹,Chapela Rocío¹⁰,Rodriguez-Cintron William¹¹,Rodríguez-Santana Jose R.¹³,Romieu Isabelle¹²,Sienra-Monge Juan José¹³,Navarro Blanca del Rio¹³,London Stephanie J.¹⁴,Ruiz-Linares Andrés⁵,Garcia-Herrera Rodrigo³,Estrada Karol³,Hidalgo-Miranda Alfredo³,Jimenez-Sanchez Gerardo³,Carnevale Alessandra³,Soberón Xavier³,Canizales-Quinteros Samuel³¹⁵,Rangel-Villalobos Héctor⁷,Silva-Zolezzi Irma³,Burchard Esteban Gonzalez⁶²,Bustamante Carlos D.¹

Affiliation:

1. Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.

2. Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.

3. Instituto Nacional de Medicina Genómica (INMEGEN), Mexico City, Mexico.

4. Escuela Nacional de Antropología e Historia (ENAH), Mexico City, Mexico.

5. Department of Genetics, Evolution and Environment, University College London, London, UK.

6. Department of Medicine, University of California, San Francisco, CA, USA.

7. Instituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexico.

8. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

9. The Brooklyn Hospital Center, Brooklyn, NY, USA.

10. Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City, Mexico.

11. Veterans Caribbean Health Care System, San Juan, Puerto Rico.

12. International Agency for Research on Cancer, Lyon, France.

13. Hospital Infantil de México Federico Gomez, Mexico City, Mexico.

14. National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.

15. Facultad de Química, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Abstract

The population structure of Native Mexicans The genetics of indigenous Mexicans exhibit substantial geographical structure, some as divergent from each other as are existing populations of Europeans and Asians. By performing genome-wide analyses on Native Mexicans from differing populations, Moreno-Estrada et al. successfully recapitulated the pre-Columbian substructure of Mexico. This ancestral structure is evident among cosmopolitan Mexicans and is correlated with subcontinental origins and medically relevant aspects of lung function. These findings exemplify the importance of understanding the genetic contributions of admixed individuals. Science , this issue p. 1280

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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